The InteractX download to a Runtime HMI system requires exiting the running application on the HMI and manually shutting down the running InteractX COMM Server service if it is still visible in the Windows System Tray.
If you are not sure it is closed, in the Deployment Server, you can set the unit to NOT run InteractX on boot and do a Windows Restart so the COMM server is not opened.
The reason this is required is that when the COMM server is open, it is not possible for the download to replace the configuration file used by the COMM Server unless the COMM Server is not running. Other application changes that do not effect the COMM Server will download and work without shutting down first since the COMM Server configuration file does not need replaced.
Then, when the download completes, open the Deployment Server and set it to Launch InteractX at Startup and hit the Apply button. Then you can use the Launch InteractX button to put the unit back into runtime.